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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
XIAP
All Species:
3.33
Human Site:
S421
Identified Species:
6.67
UniProt:
P98170
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P98170
NP_001158.2
497
56685
S421
L
V
N
A
Q
K
D
S
M
Q
D
E
S
S
Q
Chimpanzee
Pan troglodytes
Q95M72
236
27118
P179
R
E
I
S
P
E
E
P
L
R
R
L
Q
D
E
Rhesus Macaque
Macaca mulatta
XP_001114854
292
33120
L235
F
F
V
L
G
R
N
L
N
I
R
S
E
S
D
Dog
Lupus familis
XP_538165
615
69039
H539
L
V
S
A
Q
K
D
H
T
Q
D
E
S
S
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q60989
496
56061
N420
L
V
S
A
Q
K
D
N
T
E
D
E
S
S
Q
Rat
Rattus norvegicus
Q9R0I6
496
56054
N420
L
V
S
A
Q
K
D
N
S
Q
D
E
S
S
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509526
607
68021
T430
L
L
N
A
E
D
E
T
R
E
E
E
K
E
R
Chicken
Gallus gallus
Q90660
611
68991
K434
L
L
T
A
E
D
E
K
R
E
E
E
K
E
R
Frog
Xenopus laevis
A5D8Q0
488
55110
I426
D
K
P
M
K
R
E
I
S
I
E
E
K
L
R
Zebra Danio
Brachydanio rerio
NP_919377
405
45574
E348
K
A
E
D
P
M
T
E
L
E
K
L
Q
R
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24307
498
54520
E439
P
N
G
N
L
S
L
E
E
E
N
R
Q
L
K
Honey Bee
Apis mellifera
XP_396819
518
59795
H442
E
I
S
M
I
F
N
H
T
A
N
K
K
T
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
39
57.7
70.2
N.A.
89.1
89.7
N.A.
28.6
29.6
50
39.4
N.A.
33.7
35.3
N.A.
N.A.
Protein Similarity:
100
44.2
58.1
74.6
N.A.
94.1
95.5
N.A.
45.6
45.1
69.6
56.7
N.A.
51.2
54.4
N.A.
N.A.
P-Site Identity:
100
0
6.6
80
N.A.
73.3
80
N.A.
26.6
20
6.6
0
N.A.
0
0
N.A.
N.A.
P-Site Similarity:
100
40
20
86.6
N.A.
93.3
93.3
N.A.
73.3
60
40
20
N.A.
20
40
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
50
0
0
0
0
0
9
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
9
0
17
34
0
0
0
34
0
0
9
9
% D
% Glu:
9
9
9
0
17
9
34
17
9
42
25
59
9
17
17
% E
% Phe:
9
9
0
0
0
9
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
9
0
9
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
17
0
0
0
0
0
0
0
% H
% Ile:
0
9
9
0
9
0
0
9
0
17
0
0
0
0
0
% I
% Lys:
9
9
0
0
9
34
0
9
0
0
9
9
34
0
9
% K
% Leu:
50
17
0
9
9
0
9
9
17
0
0
17
0
17
0
% L
% Met:
0
0
0
17
0
9
0
0
9
0
0
0
0
0
0
% M
% Asn:
0
9
17
9
0
0
17
17
9
0
17
0
0
0
9
% N
% Pro:
9
0
9
0
17
0
0
9
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
34
0
0
0
0
25
0
0
25
0
34
% Q
% Arg:
9
0
0
0
0
17
0
0
17
9
17
9
0
9
25
% R
% Ser:
0
0
34
9
0
9
0
9
17
0
0
9
34
42
0
% S
% Thr:
0
0
9
0
0
0
9
9
25
0
0
0
0
9
0
% T
% Val:
0
34
9
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _